TLR3 anticorps

N° du produit ABIN2798861

L’anticorps Lapin Polyclonal anti-TLR3 a été validé pour WB et IHC. Il convient pour détecter TLR3 dans des échantillons de Humain.

Aperçu rapide pour TLR3 anticorps (ABIN2798861)

Antigène: TLR3 (Toll-Like Receptor 3 (TLR3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLR3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-TLR3 anticorps

Fonction: Rabbit Anti-Human TLR3 Antibody

Immunogène: This TLR3 antibody is generated from rabbits immunized with TLR3 recombinant protein.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100Western blot analysis of TLR3 Antibody was detected using the purified Pab.
Formalin-fixed and paraffin-embedded mouse brain tissue reacted with TLR3 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur TLR3

Antigène: TLR3 (Toll-Like Receptor 3 (TLR3))

Autre désignation: TLR3

Sujet:

Target Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Gene Symbol: TLR3

Poids moléculaire: 103829 Da

ID gène: 7098

UniProt: O15455

Pathways: Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades