TLR6 anticorps (C-Term)

N° du produit ABIN2798862

Cet anticorps anti-TLR6 est un anticorps Lapin Polyclonal détectant TLR6 dans WB, IHC et FACS. Adapté pour Humain.

Aperçu rapide pour TLR6 anticorps (C-Term) (ABIN2798862)

Antigène: TLR6 (Toll-Like Receptor 6 (TLR6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLR6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Détail du produit anti-TLR6 anticorps

Épitope: AA 393-423, C-Term

Fonction: Rabbit Anti-Human TLR6 (C-term) Antibody

Immunogène: This TLR6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 393-423 amino acids from the C-terminal region of human TLR6.

Isotype: Ig Fraction

Information d'application

Indications d'application: Flow Cytometry, Western Blot, Immunohistochemistry
Recommended Dilutions
FC: 1:10-50, WB: 1:1000, IHC: 1:50-100Flow cytometric analysis of NCI-H460 cells using TLR6 Antibody (C-term) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.Western blot analysis of anti-TLR6 Pab , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 2.0 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur TLR6

Antigène: TLR6 (Toll-Like Receptor 6 (TLR6))

Autre désignation: TLR6

Sujet:

Target Description: TLR6, a Type I membrane protein that belongs to the Toll-like rceptor family, participates in the innate immune response to Gram-positive bacteria and fungi. It acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. It binds to TLR2 via their respective extracellular domains, and to MyD88 via their respective TIR domains. TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

Gene Symbol: TLR6

Poids moléculaire: 91880 Da

ID gène: 10333

UniProt: Q9Y2C9

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades