USP7 anticorps (Center)

N° du produit ABIN2799159

Cet anticorps anti-USP7 est un anticorps Lapin Polyclonal détectant USP7 dans WB. Adapté pour Humain.

Aperçu rapide pour USP7 anticorps (Center) (ABIN2799159)

Antigène: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP7 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-USP7 anticorps

Épitope: AA 320-348, Center

Fonction: Rabbit Anti-Human USP7 (Center) Antibody

Immunogène: This USP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-348 amino acids from the Central region of human USP7.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western Blot
Recommended Dilutions
WB: 1:1000USP7 Antibody (Center) .

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.450 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur USP7

Antigène: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Autre désignation: USP7

Sujet:

Target Description: Hydrolase that deubiquitinates target proteins such as FOXO4, TP53, MDM2, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and proteasomal degradation. Deubiquitinates TP53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.

Gene Symbol: USP7

Poids moléculaire: 128302 Da

ID gène: 7874

UniProt: Q93009