CRTC1 anticorps (AbBy Fluor® 594)

N° du produit ABIN2807130

Cet anticorps Lapin Polyclonal détecte spécifiquement CRTC1 dans WB et IF (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour CRTC1 anticorps (AbBy Fluor® 594) (ABIN2807130)

Antigène: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRTC1 est conjugé à/à la AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-CRTC1 anticorps (AbBy Fluor® 594)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TORC1

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur CRTC1

Antigène: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Autre désignation: TORC1/ CRTC1

Sujet:

Synonyms: CREB regulated transcription coactivator 1, CRTC1, KIAA0616, MECT 1, Mucoepidermoid carcinoma translocated protein 1, also known as MucoEpidermoid Carcinoma Translocated 1, TORC1, Transducer of CREB protein 1, Transducer of regulated cAMP response element binding protein 1, WAMTP1.

Background: which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11,19) (q21,p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.

ID gène: 23373