SLUG anticorps (Middle Region)

N° du produit ABIN2853627

Cité dans 3 publications. Cet anticorps anti-SLUG Polyclonal Lapin (ABIN2853627) détecte spécifiquement SLUG dans WB, IHC (p) et EIA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour SLUG anticorps (Middle Region) (ABIN2853627)

Antigène: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLUG est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-SLUG anticorps

Épitope: Middle Region

Specificité: This antibody detects SLUG at center.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human SLUG.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-SLUG (ABIN2853627)

Huo, Kao, Chuu: "Androgen receptor inhibits epithelial-mesenchymal transition, migration, and invasion of PC-3 prostate cancer cells." dans: Cancer letters, Vol. 369, Issue 1, pp. 103-11, (2015) (PubMed).

Ferrari-Amorotti, Fragliasso, Esteki, Prudente, Soliera, Cattelani, Manzotti, Grisendi, Dominici, Pieraccioli, Raschellà, Chiodoni, Colombo, Calabretta: "Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion." dans: Cancer research, Vol. 73, Issue 1, pp. 235-45, (2013) (PubMed).

Lemma, Karihtala, Haapasaari, Jantunen, Soini, Bloigu, Pasanen, Turpeenniemi-Hujanen, Kuittinen: "Biological roles and prognostic values of the epithelial-mesenchymal transition-mediating transcription factors Twist, ZEB1 and Slug in diffuse large B-cell lymphoma." dans: Histopathology, Vol. 62, Issue 2, pp. 326-33, (2012) (PubMed).

Détails sur SLUG

Antigène: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Autre désignation: SNAI2 / SLUG

Sujet: SLUG is a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects.Synonyms: Neural crest transcription factor Slug, Protein snail homolog 2, SLUGH, Zinc finger protein SNAI2

Poids moléculaire: 29986 Da

ID gène: 6591, 9606

UniProt: O43623