LIG1 anticorps (C-Term)

N° du produit ABIN2854412

L’anticorps Lapin Polyclonal anti-LIG1 a été validé pour WB. Il convient pour détecter LIG1 dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour LIG1 anticorps (C-Term) (ABIN2854412)

Antigène: LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LIG1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-LIG1 anticorps

Épitope: C-Term

Réactivité croisée: Humain

Attributs du produit: Rabbit polyclonal antibody to DNA ligase I (ligase I, DNA, ATP-dependent)
DNA ligase I antibody [C2C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human DNA ligase I. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: A431 , H1299

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-LIG1 (ABIN2854412)

Liddiard, Ruis, Kan, Cleal, Ashelford, Hendrickson, Baird: "DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase." dans: Nucleic acids research, Vol. 47, Issue 5, pp. 2402-2424, (2019) (PubMed).

Détails sur LIG1

Antigène: LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))

Autre désignation: DNA ligase 1

Sujet: LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.

Cellular Localization: Nucleus

Poids moléculaire: 102 kDa

ID gène: 3978

UniProt: P18858

Pathways: Telomere Maintenance, Réparation de l'ADN, DNA Replication, Synthesis of DNA