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Dynactin 1 anticorps (C-Term)

DCTN1 Reactivité: Humain WB, IF, ICC, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2854663
  • Antigène Voir toutes Dynactin 1 (DCTN1) Anticorps
    Dynactin 1 (DCTN1)
    Épitope
    • 15
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 55
    • 23
    • 17
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 38
    • 14
    • 3
    • 1
    Lapin
    Clonalité
    • 42
    • 14
    Polyclonal
    Conjugué
    • 35
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Dynactin 1 est non-conjugé
    Application
    • 47
    • 17
    • 13
    • 13
    • 13
    • 8
    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Rabbit Polyclonal antibody to DCTN1 (dynactin 1)
    DCTN1 antibody [C3], C-term
    Purification
    Purified by antigen-affinity chromatography.
    Immunogène
    Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human DCTN1. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product DCTN1 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Commentaires

    Positive Control: rat brain , U87-MG , SK-N-SH , IMR32 , SK-N-AS , Jurkat , Raji , NCI-H929 , mouse brain , mouse lung

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
    Agent conservateur
    Thimerosal (Merthiolate)
    Précaution d'utilisation
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Antigène
    Dynactin 1 (DCTN1)
    Autre désignation
    dynactin subunit 1 (DCTN1 Produits)
    Synonymes
    anticorps DAP-150, anticorps DP-150, anticorps P135, anticorps Chip150, anticorps DCTN1, anticorps DKFZp469C1813, anticorps AL022633, anticorps Glued, anticorps p150, anticorps p150, anticorps CG9206, anticorps DYNA_DROME, anticorps Dmel\\CG9206, anticorps FCP-D, anticorps Glu, anticorps P150, anticorps P150[Glued], anticorps p150/Glued, anticorps p150/glued, anticorps p150[Glued], anticorps p150[glued], anticorps t1, anticorps Dynactin-1, anticorps glued, anticorps dynactin subunit 1, anticorps dynactin 1, anticorps Dynactin 1, p150 subunit, anticorps dynactin subunit 1 L homeolog, anticorps DCTN1, anticorps Dctn1, anticorps DCTN1-p150, anticorps dctn1.L
    Sujet
    This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

    Cellular Localization: Cytoplasm , cytoskeleton
    Poids moléculaire
    142 kDa
    ID gène
    1639
    UniProt
    Q14203
    Pathways
    M Phase, ER-Nucleus Signaling
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