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HTR2C anticorps (C-Term)

HTR2C Reactivité: Humain WB, IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2854715
  • Antigène Voir toutes HTR2C Anticorps
    HTR2C (5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C))
    Épitope
    • 15
    • 10
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 72
    • 45
    • 44
    • 7
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Humain
    Hôte
    • 69
    • 3
    • 1
    Lapin
    Clonalité
    • 62
    • 11
    Polyclonal
    Conjugué
    • 35
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HTR2C est non-conjugé
    Application
    • 59
    • 32
    • 14
    • 13
    • 13
    • 13
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Rabbit Polyclonal antibody to 5-HT2C receptor
    5-HT2C receptor antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogène
    Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human 5-HT2C receptor. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product HTR2C Anticorps primaire
  • Indications d'application
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Commentaires

    Positive Control: rat brain , mouse placenta

    Validation: Orthogonal

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.68 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Agent conservateur
    Thimerosal (Merthiolate)
    Précaution d'utilisation
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Antigène
    HTR2C (5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C))
    Autre désignation
    5-hydroxytryptamine receptor 2C (HTR2C Produits)
    Synonymes
    anticorps 5-HT2C, anticorps 5-HTR2C, anticorps HTR1C, anticorps 5-HT2cR, anticorps 5HT1c, anticorps Htr1c, anticorps SR1, anticorps 5HT-1C, anticorps 5HT2C, anticorps 5-HT-2C, anticorps 5-ht2cr, anticorps si:dkey-24g18.2, anticorps 5ht2c, anticorps 5HTR2C, anticorps 5-hydroxytryptamine receptor 2C, anticorps 5-hydroxytryptamine (serotonin) receptor 2C, anticorps 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled S homeolog, anticorps 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1, anticorps 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, anticorps HTR2C, anticorps Htr2c, anticorps htr2c.S, anticorps htr2cl1, anticorps LOC407134
    Sujet
    Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.

    Cellular Localization: Cell membrane
    Poids moléculaire
    52 kDa
    ID gène
    3358
    UniProt
    P28335
    Pathways
    Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour
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