POLG anticorps (C-Term)

N° du produit ABIN2854742

L’anticorps Lapin Polyclonal anti-POLG a été validé pour WB, ICC, IHC (p), IP et IF. Il convient pour détecter POLG dans des échantillons de Humain.

Aperçu rapide pour POLG anticorps (C-Term) (ABIN2854742)

Antigène: POLG (Polymerase (DNA Directed), gamma (POLG))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLG est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-POLG anticorps

Épitope: C-Term

Réactivité croisée: Humain, Rat

Attributs du produit: Rabbit Polyclonal antibody to DNA polymerase gamma (polymerase (DNA directed), gamma)
DNA polymerase gamma antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human DNA polymerase gamma. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Rat testis , MCF-7 , MDA-MB-231

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.67 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur POLG

Antigène: POLG (Polymerase (DNA Directed), gamma (POLG))

Autre désignation: DNA polymerase gamma

Sujet: Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Cellular Localization: Mitochondrion

Poids moléculaire: 140 kDa

ID gène: 5428

UniProt: P54098