MMP1 anticorps

N° du produit ABIN2854783

Cet anticorps Lapin Polyclonal détecte spécifiquement MMP1 dans WB, IF, ICC et IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 5+ publications.

Aperçu rapide pour MMP1 anticorps (ABIN2854783)

Antigène: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-MMP1 anticorps

Réactivité croisée: Humain, Souris

Attributs du produit: Rabbit Polyclonal antibody to MMP1 (matrix metallopeptidase 1 (interstitial collagenase))
MMP1 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human MMP1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Validation: Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.7 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-MMP1 (ABIN2854783)

Bordignon, Bottoni, Xu, Popescu, Truan, Guenova, Kofler, Jafari, Ostano, Röcken, Neel, Dotto: "Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant." dans: Cell reports, Vol. 28, Issue 9, pp. 2358-2372.e6, (2020) (PubMed).

Wu, Lin, Hou, Chang, Wen, Lin, Chiang: "1,2-Bis[(3-Methoxyphenyl)Methyl]Ethane-1,2-Dicarboxylic Acid Reduces UVB-Induced Photodamage In Vitro and In Vivo." dans: Antioxidants (Basel, Switzerland), Vol. 8, Issue 10, (2019) (PubMed).

Dubey, Wei, Yu, Williams, Wang, Deng, Tsai, Wang, Deng: "Adipose-derived Stem Cells Attenuates Diabetic Osteoarthritis via Inhibition of Glycation-mediated Inflammatory Cascade." dans: Aging and disease, Vol. 10, Issue 3, pp. 483-496, (2019) (PubMed).

Olaya-C, Garrido, Hernandez-Losa, Sesé, Ayala-Ramirez, Somoza, Vargas, Ramón Y Cajal: "The umbilical cord, preeclampsia and the VEGF family." dans: International journal of women's health, Vol. 10, pp. 783-795, (2018) (PubMed).

Kim, Choi, Lee, Soh, Kim, Park: "Senescent tumor cells lead the collective invasion in thyroid cancer." dans: Nature communications, Vol. 8, pp. 15208, (2018) (PubMed).

Détails sur MMP1

Antigène: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Autre désignation: matrix metallopeptidase 1

Sujet: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Cellular Localization: Secreted , extracellular space , extracellular matrix

Poids moléculaire: 54 kDa

ID gène: 4312

UniProt: P03956