BMP4 anticorps

N° du produit ABIN2854883

Détail du produit anti-BMP4 anticorps

Antigène: BMP4 (Bone Morphogenetic Protein 4 (BMP4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BMP4 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody is able to recognize full length BMP4 protein (~55 kDa) and N-terminal propeptide BMP4 protein (~40 kDa) but unable to detect mature form.

Réactivité croisée: Humain, Souris

Attributs du produit: Rabbit Polyclonal antibody to BMP4 (bone morphogenetic protein 4)
BMP4 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human BMP4. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: NIH-3T3 , JC , HepG2 conditioned medium

Validation: Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.36 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-BMP4 (ABIN2854883)

Guo, Wang, Yuan, Zhu, Fu, Xu, Wu, Wu: "TSA restores hair follicle-inductive capacity of skin-derived precursors." dans: Scientific reports, Vol. 9, Issue 1, pp. 2867, (2020) (PubMed).

Peng, Chen, Wang, Zhu, Wu, Luo, Zuo, Luo, Zhou, Shi, Weng, Huang, He, Fan: "Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes." dans: Aging, Vol. 11, Issue 23, pp. 11520-11540, (2019) (PubMed).

Détails sur BMP4

Antigène: BMP4 (Bone Morphogenetic Protein 4 (BMP4))

Autre désignation: bone morphogenetic protein 4 (BMP4 Produits)

Synonymes: anticorps BMP2B, anticorps BMP2B1, anticorps MCOPS6, anticorps OFC11, anticorps ZYME, anticorps Bmp-4, anticorps Bmp2b, anticorps Bmp2b-1, anticorps Bmp2b1, anticorps BOMPR4A, anticorps bmp-4, anticorps zbmp-4, anticorps zgc:100779, anticorps BMP-4, anticorps XBMP-4, anticorps bmp2b, anticorps bmp2b1, anticorps bmp4, anticorps ofc11, anticorps xbmp4, anticorps zyme, anticorps BMP4, anticorps bone morphogenetic protein 4, anticorps bone morphogenetic protein 4 L homeolog, anticorps bone morphogenetic protein 4 S homeolog, anticorps BMP4, anticorps Bmp4, anticorps bmp4, anticorps bmp4.L, anticorps bmp4.S

Sujet: The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

Cellular Localization: Secreted , extracellular space , extracellular matrix

Poids moléculaire: 47 kDa

ID gène: 652

UniProt: P12644

Pathways: Steroid Hormone Mediated Signaling Pathway, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development