GLA anticorps

N° du produit ABIN2854962

Cet anticorps anti-GLA est un anticorps Lapin Polyclonal détectant GLA dans WB, IP et IHC (p). Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour GLA anticorps (ABIN2854962)

Antigène: GLA (Galactosidase, alpha (GLA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLA est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: KO Validated

Détail du produit anti-GLA anticorps

Specificité: Knockdown/Knockout validation was supported by customer review data.

Réactivité croisée: Humain, Rat

Attributs du produit: Rabbit Polyclonal antibody to Galactosidase alpha (galactosidase, alpha)
Galactosidase alpha antibody [N1C2]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human Galactosidase alpha. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: HeLa , 293T , Rat lung

Validation: KO/KD

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.157 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-GLA (ABIN2854962)

Ivanova, Dao, Kasaci, Adewale, Fikry, Goker-Alpan: "Rapid Clathrin-Mediated Uptake of Recombinant α-Gal-A to Lysosome Activates Autophagy." dans: Biomolecules, Vol. 10, Issue 6, (2020) (PubMed).

Hingorani, Metcalf, Deming, Garman, Powers, Gierasch: "Ligand-promoted protein folding by biased kinetic partitioning." dans: Nature chemical biology, Vol. 13, Issue 4, pp. 369-371, (2017) (PubMed).

Détails sur GLA

Antigène: GLA (Galactosidase, alpha (GLA))

Autre désignation: galactosidase alpha

Sujet: This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

Cellular Localization: Lysosome

Poids moléculaire: 49 kDa

ID gène: 2717

UniProt: P06280

Pathways: SARS-CoV-2 Protein Interactome