Transferrin Receptor anticorps
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- Antigène Voir toutes Transferrin Receptor (TFRC) Anticorps
- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Transferrin Receptor est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Réactivité croisée
- Humain, Souris
- Attributs du produit
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Rabbit Polyclonal antibody to CD71 (transferrin receptor (p90, CD71))
CD71 antibody [N2C1], Internal - Purification
- Purified by antigen-affinity chromatography.
- Classe de qualité
- KO Validated
- Immunogène
- Recombinant protein encompassing a sequence within the center region of human CD71. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product TFRC Anticorps primaire
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- Indications d'application
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Commentaires
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Positive Control: Jurkat , Raji , NCI-H929 , K562 , HL-60 , NIH3T3 , HeLa
Validation: Comparison, KO/KD
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.47 mg/mL
- Buffer
- 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases." dans: Cell death discovery, Vol. 7, Issue 1, pp. 164, (2021) (PubMed).
: "African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin." dans: Nature communications, Vol. 11, Issue 1, pp. 473, (2020) (PubMed).
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The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases." dans: Cell death discovery, Vol. 7, Issue 1, pp. 164, (2021) (PubMed).
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- Antigène
- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
- Autre désignation
- transferrin receptor (TFRC Produits)
- Synonymes
- anticorps Trfr, anticorps LOC100219280, anticorps tfr, anticorps cd71, anticorps tfr1, anticorps trfr, anticorps CD71, anticorps T9, anticorps TFR, anticorps TFR1, anticorps TR, anticorps TRFR, anticorps p90, anticorps 2610028K12Rik, anticorps AI195355, anticorps AI426448, anticorps AU015758, anticorps E430033M20Rik, anticorps Mtvr-1, anticorps Mtvr1, anticorps transferrin receptor, anticorps TFRC, anticorps Tfrc, anticorps tfrc
- Sujet
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Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Cellular Localization: Cell membrane, Single-pass type II membrane protein , Melanosome , Transferrin receptor protein 1 , serum form: Secreted - Poids moléculaire
- 85 kDa
- ID gène
- 7037
- UniProt
- P02786
- Pathways
- Transition Metal Ion Homeostasis
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