MSH3 anticorps (N-Term)

N° du produit ABIN2855583

Cet anticorps anti-MSH3 est un anticorps Lapin Polyclonal détectant MSH3 dans WB. Adapté pour Humain.

Aperçu rapide pour MSH3 anticorps (N-Term) (ABIN2855583)

Antigène: MSH3 (MutS Homolog 3 (MSH3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MSH3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MSH3 anticorps

Épitope: N-Term

Réactivité croisée: Boeuf (Vache)

Réactivité croisée (Details): Bovine (83 %)

Attributs du produit: Rabbit Polyclonal antibody to MSH3 (mutS homolog 3 (E. coli))
MSH3 antibody [N1N2], N-term

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the N-terminus region of human MSH3. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*

Commentaires:

Positive Control: A549 , H1299 , HCT116

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur MSH3

Antigène: MSH3 (MutS Homolog 3 (MSH3))

Autre désignation: MSH3

Sujet: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Poids moléculaire: 127 kDa

ID gène: 4437

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response