CD22 anticorps

N° du produit ABIN2855664

Détail du produit anti-CD22 anticorps

Antigène: CD22 (CD22 Molecule (CD22))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD22 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Attributs du produit: Rabbit polyclonal antibody to CD22 (CD22 Molecule)
CD22 antibody [N2C3]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human CD22. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000-1:10000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Raji

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur CD22

Antigène: CD22 (CD22 Molecule (CD22))

Autre désignation: CD22 molecule (CD22 Produits)

Synonymes: anticorps A530093D23, anticorps Lyb-8, anticorps Lyb8, anticorps SIGLEC-2, anticorps SIGLEC2, anticorps siglec-2, anticorps CD22 antigen, anticorps CD22 molecule, anticorps Cd22, anticorps CD22

Sujet: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Cellular Localization: Cell membrane

Poids moléculaire: 95 kDa

ID gène: 933

UniProt: P20273