CTNNA1 anticorps

N° du produit ABIN2856243

Détail du produit anti-CTNNA1 anticorps

Antigène: CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CTNNA1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Cat, Chien, Humain, Souris, Rat

Attributs du produit: Rabbit Polyclonal antibody to alpha 1 Catenin (catenin (cadherin-associated protein), alpha 1, 102 kDa)
alpha 1 Catenin antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human alpha 1 Catenin. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:10000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Mouse brain , rat brain

Validation: Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.11 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur CTNNA1

Antigène: CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))

Autre désignation: catenin alpha 1 (CTNNA1 Produits)

Synonymes: anticorps CAP102, anticorps 2010010M04Rik, anticorps AA517462, anticorps AI988031, anticorps Catna1, anticorps CG17947, anticorps CT39986, anticorps Dalpha-Cat, anticorps Dalpha-cat, anticorps DalphaC, anticorps Dalphacat, anticorps Dmcatp, anticorps Dmel\\CG17947, anticorps a-Cat, anticorps a-cat, anticorps alpha-CAT, anticorps alpha-cat, anticorps alpha-catenin, anticorps alpha-ctn, anticorps alphaCAT, anticorps alphaCat, anticorps alphacat, anticorps Alpha-Cat, anticorps dgri_GLEANR_3829, anticorps DgriGH19548, anticorps GH19548, anticorps ctnna, anticorps cap102, anticorps catna1, anticorps ctnna1, anticorps catenin alpha 1, anticorps catenin (cadherin associated protein), alpha 1, anticorps alpha Catenin, anticorps catenin alpha-1, anticorps catenin (cadherin-associated protein), alpha 1, anticorps catenin alpha 1 S homeolog, anticorps CTNNA1, anticorps Ctnna1, anticorps alpha-Cat, anticorps Dgri\alpha-Cat, anticorps Tsp_10127, anticorps ctnna1, anticorps ctnna1.S

Sujet: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Cellular Localization: Cytoplasm , cytoskeleton , Cell junction , adherens junction , Cell membrane

Poids moléculaire: 100 kDa

ID gène: 1495

UniProt: P35221

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location