RAMP2 anticorps (C-Term)

N° du produit ABIN2856615

Cité dans 2+ publications. Cet anticorps anti-RAMP2 est un anticorps Polyclonal produit chez le Lapin, détectant RAMP2 dans WB, IHC (p) et IHC (fro). Convient pour Humain.

Aperçu rapide pour RAMP2 anticorps (C-Term) (ABIN2856615)

Antigène: RAMP2 (Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAMP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-RAMP2 anticorps

Épitope: C-Term

Réactivité croisée: Humain, Souris

Attributs du produit: Rabbit Polyclonal antibody to RAMP2 (receptor (G protein-coupled) activity modifying protein 2)
RAMP2 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human RAMP2. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Validation: Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-RAMP2 (ABIN2856615)

Edvinsson, Grell, Warfvinge: "Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion." dans: Journal of molecular neuroscience : MN, Vol. 70, Issue 6, pp. 930-944, (2020) (PubMed).

Blom, Giove, Pong, Blute, Eldred: "Evidence for a functional adrenomedullin signaling pathway in the mouse retina." dans: Molecular vision, Vol. 18, pp. 1339-53, (2012) (PubMed).

Détails sur RAMP2

Antigène: RAMP2 (Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2))

Autre désignation: receptor activity modifying protein 2

Sujet: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.

Cellular Localization: Membrane, Single-pass type I membrane protein

Poids moléculaire: 20 kDa

ID gène: 10266

UniProt: O60895

Pathways: cAMP Metabolic Process, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling