ANO1 anticorps (AA 904-986)

N° du produit ABIN2962568

Cet anticorps anti-ANO1 Monoclonal Souris (Clone DOG1-1) (ABIN2962568) détecte spécifiquement ANO1 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ANO1 anticorps (AA 904-986) (ABIN2962568)

Antigène: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ANO1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: DOG1-1

Détail du produit anti-ANO1 anticorps

Épitope: AA 904-986

Specificité: Reacts with human DOG1.

Purification: Purified (protein G)

Immunogène: Synthetic peptide corresponding to aa 904-986 of human DOG1 (accession no. Q5XXA6).

Isotype: IgG1

Information d'application

Indications d'application: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC(1 - 10 μg/mL)

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.4

Conseil sur la manipulation: Dilute in PBS or medium which is identical to that used in the assay system.

Stock: -20 °C

Stockage commentaire: This antibody is stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Détails sur ANO1

Antigène: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Autre désignation: DOG1

Sujet: DOG1 (Discovered on GIST1), also known as TMEM16A and ANO1, has emerged in recent years as a promising biomarker for gastrointestinal stromal tumors (GIST). It was originally discovered through microarray expression profiling analysis as a gene that is highly expressed in GIST, and subsequent immunohistochemical studies have shown its use in its diagnosis. DOG1 antibodies are more sensitive than KIT antibodies in detecting tumors of gastric origin, tumors with epithelioid morphology, and tumors harboring PDGFRA mutation. DOG1 immunoreactivity is rarely observed in other mesenchymal and nonmesenchymal tumor types. These results support the use of DOG1 as a biomarker for GIST.

Anoctamin 1, ANO1 Calcium activated chloride channel Discovered on gastrointestinal stromal tumors protein 1 Oral cancer overexpressed protein 2, ORAOV2 Transmembrane protein 16A, TMEM16A Tumor-amplified and overexpressed sequence 2, TAOS2 Gene name : ANO1

ID gène: 55107

UniProt: Q5XXA6