ITGA4 anticorps

N° du produit ABIN2967175

Cet anticorps anti-ITGA4 Monoclonal Souris (Clone 9F10) (ABIN2967175) détecte spécifiquement ITGA4 dans FACS, IHC (fro) et Func. L’anticorps est réactif avec des échantillons de Humain, Boeuf (Vache), Chien, Cheval, Cat, Mouton et Non-Human Primate.

Aperçu rapide pour ITGA4 anticorps (ABIN2967175)

Antigène: ITGA4 (Integrin alpha 4 (ITGA4))

Reactivité: Humain, Boeuf (Vache), Chien, Cheval, Cat, Mouton, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGA4 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Clone: 9F10

Détail du produit anti-ITGA4 anticorps

Fonction: Anti-Hu CD49d Purified Low Endotoxin

Specificité: The mouse monoclonal antibody 9F10 recognizes an extracellular epitope of CD49d (alpha 4 integrin), a 145-180 kDa type I transmembrane glycoprotein expressed on B and T cells, monocytes, eosinophils, basophils, NK cells, and dendritic cells, but not platelets.

Réactivité croisée (Details): Human, Non-Human Primates, Bovine, Canine (Dog), Equine (Horse), Feline (Cat), Sheep

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

niveau d'endotoxine: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Functional application: In vitro T cell costimulation.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détails sur ITGA4

Antigène: ITGA4 (Integrin alpha 4 (ITGA4))

Autre désignation: CD49d

Sujet: Integrin subunit alpha 4,CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.,ITGA4, VLA-4 alpha

ID gène: 3676

UniProt: P13612

Pathways: Integrin Complex