ITGA4 anticorps

N° du produit ABIN2967176

Cet anticorps Souris Monoclonal détecte spécifiquement ITGA4 dans FACS et IHC (fro). Il présente une réactivité avec des échantillons de Humain, Boeuf (Vache), Chien, Cheval, Cat, Mouton et Non-Human Primate.

Aperçu rapide pour ITGA4 anticorps (ABIN2967176)

Antigène: ITGA4 (Integrin alpha 4 (ITGA4))

Reactivité: Humain, Boeuf (Vache), Chien, Cheval, Cat, Mouton, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGA4 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 9F10

Détail du produit anti-ITGA4 anticorps

Fonction: Anti-Hu CD49d Purified

Réactivité croisée (Details): Human, Non-Human Primates, Bovine, Canine (Dog), Equine (Horse), Feline (Cat), Sheep

Attributs du produit: The mouse monoclonal antibody 9F10 recognizes an extracellular epitope of CD49d (alpha 4 integrin), a 145-180 kDa type I transmembrane glycoprotein expressed on B and T cells, monocytes, eosinophils, basophils, NK cells, and dendritic cells, but not platelets.

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Immunohistochemistry: Recommended dilution: 5-10 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détails sur ITGA4

Antigène: ITGA4 (Integrin alpha 4 (ITGA4))

Autre désignation: CD49d

Sujet: Integrin subunit alpha 4,CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.,ITGA4, VLA-4 alpha

ID gène: 3676

UniProt: P13612

Pathways: Integrin Complex