PKM anticorps (AA 11-221)

N° du produit ABIN3020838

Cet anticorps Lapin Polyclonal détecte spécifiquement PKM dans WB et IF. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour PKM anticorps (AA 11-221) (ABIN3020838)

Antigène: PKM (Pyruvate Kinase M1/2 (PKM))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKM est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-PKM anticorps

Épitope: AA 11-221

Séquence: AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT IGPASRSVET LKEMIKSGMN VARLNFSHGT HEYHAETIKN VRTATESFAS DPILYRPVAV ALDTKGPEIR TGLIKGSGTA EVELKKGATL KITLDNAYME KCDENILWLD YKNICKVVEV GSKIYVDDGL ISLQVKQKGA DFLVTEVENG GSLGSKKGVN LPGAAVDLPA V

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 11-221 of human PKM2 (NP_002645.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:20 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-PKM (ABIN3020838)

Wei, Dai, Zhou, He, Yao, Zhao, Guo, Yang: "Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression." dans: Cell death & disease, Vol. 8, Issue 7, pp. e2944, (2018) (PubMed).

Wang, Jiang, Ji, Cai, Chen, Yu, Zhu, Zhang: "PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer." dans: Scientific reports, Vol. 7, Issue 1, pp. 2886, (2018) (PubMed).

Zou, Wang, Hu, Zheng, Xu, Li: "Specific tumor-derived CCL2 mediated by pyruvate kinase M2 in colorectal cancer cells contributes to macrophage recruitment in tumor microenvironment." dans: Tumour biology, Vol. 39, Issue 3, pp. 1010428317695962, (2017) (PubMed).

Détails sur PKM

Antigène: PKM (Pyruvate Kinase M1/2 (PKM))

Autre désignation: PKM

Sujet: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.,CTHBP,HEL-S-30,OIP3,PK3,PKM2,TCB,THBP1,PKM,Epigenetics & Nuclear Signaling,RNA Binding,Cancer,Tumor biomarkers,Signal Transduction,Endocrine & Metabolism,Carbohydrate metabolism,Warburg Effect,PKM

Poids moléculaire: 56 kDa/57 kDa/58 kDa

ID gène: 5315

UniProt: P14618

Pathways: L'effet Warburg