TCL1A anticorps (AA 1-114)
Aperçu rapide pour TCL1A anticorps (AA 1-114) (ABIN3021014)
Antigène
Voir toutes TCL1A AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- AA 1-114
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Séquence
- MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD
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Réactivité croisée
- Humain
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Attributs du produit
- Polyclonal Antibodies
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Immunogène
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human TCL1A (NP_001092195.1).
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Isotype
- IgG
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Indications d'application
- WB,1:500 - 1:2000
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid freeze / thaw cycles
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Stock
- -20 °C
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Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))
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Autre désignation
- TCL1A
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Sujet
- Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010],TCL1A,TCL1,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,TCL1A
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Poids moléculaire
- 13 kDa
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ID gène
- 8115
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UniProt
- P56279
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Pathways
- Stem Cell Maintenance
Antigène
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