ACTN1 anticorps (AA 1-330)

N° du produit ABIN3021587

Cet anticorps anti-ACTN1 est un anticorps Lapin Polyclonal détectant ACTN1 dans WB et IHC. Adapté pour Humain. Ce Primary Antibody a été cité dans 3+ publications.

Aperçu rapide pour ACTN1 anticorps (AA 1-330) (ABIN3021587)

Antigène: ACTN1 (Actinin, alpha 1 (ACTN1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACTN1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-ACTN1 anticorps

Épitope: AA 1-330

Séquence: MDHYDSQQTN DYMQPEEDWD RDLLLDPAWE KQQRKTFTAW CNSHLRKAGT QIENIEEDFR DGLKLMLLLE VISGERLAKP ERGKMRVHKI SNVNKALDFI ASKGVKLVSI GAEEIVDGNV KMTLGMIWTI ILRFAIQDIS VEETSAKEGL LLWCQRKTAP YKNVNIQNFH ISWKDGLGFC ALIHRHRPEL IDYGKLRKDD PLTNLNTAFD VAEKYLDIPK MLDAEDIVGT ARPDEKAIMT YVSSFYHAFS GAQKAETAAN RICKVLAVNQ ENEQLMEDYE KLASDLLEWI RRTIPWLENR VPENTMHAMQ QKLEDFRDYR RLHKPPKVQE

Réactivité croisée: Humain, Singe, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human ACTN1 (NP_001123477.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-ACTN1 (ABIN3021587)

Zhang, Xu, Xu, Wei, Xu: "Protein kinase A inhibitor, H89, significantly enhances survival rate of dissociated human embryonic stem cells following cryopreservation." dans: Cell proliferation, Vol. 49, Issue 5, pp. 589-98, (2017) (PubMed).

Zhang, Xu, Xu, Wei, Xu: "Protein kinase A inhibitor, H89, enhances survival and clonogenicity of dissociated human embryonic stem cells through Rho-associated coiled-coil containing protein kinase (ROCK) inhibition." dans: Human reproduction (Oxford, England), Vol. 31, Issue 4, pp. 832-43, (2016) (PubMed).

Xu, Zhang, Xu, Wei, Xu: "Sensitivity of human embryonic stem cells to different conditions during cryopreservation." dans: Cryobiology, Vol. 71, Issue 3, pp. 486-92, (2016) (PubMed).

Détails sur ACTN1

Antigène: ACTN1 (Actinin, alpha 1 (ACTN1))

Autre désignation: ACTN1

Sujet: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.,ACTN1,BDPLT15,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cytoskeleton,Microfilaments,Immunology & Inflammation,T Cell Receptor Signaling Pathway,Stem Cells,ACTN1

Poids moléculaire: 102 kDa/103 kDa/105 kDa/107 kDa

ID gène: 87

UniProt: P12814

Pathways: Cell-Cell Junction Organization