CD16 anticorps

N° du produit ABIN3025888

Cet anticorps anti-CD16 est un anticorps Souris Monoclonal détectant CD16 dans FACS, IF et Func. Adapté pour Humain.

Aperçu rapide pour CD16 anticorps (ABIN3025888)

Antigène: CD16

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD16 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Clone: HuNK2

Détail du produit anti-CD16 anticorps

Purification: Protein G affinity chromatography

Immunogène: Human peripheral blood lymphocytes from a NK-leukemia patient were used as the immunogen for the CD16 antibody.

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal dilution of the CD16 antibody should be determined by the researcher.\. Functional Activity (Order SAF formulation),Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the CD16 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur CD16

Antigène: CD16

Autre désignation: CD16

Sujet: Recognizes a protein of 50-65  kDa, identified as CD16 (Workshop IV, Code N39 ) (also known low affinity Fc receptor III for IgG (FcRIII) or Leu 11). CD16 exists as a polypepetide-anchored from (FCRIIIA or CD16A) on human natural killer (NK) cells and monocytes/ macrophages and as a glycosylphosphatidylinositol (GPI)-anchored form (FcRIIIB or CD16B) on neutrophils. CD16B is polymorphic and the two alleles are termed NA1 and NA2.3 CD16 plays a role in signal transduction, NK cell activation and antibody-dependent cellular cytotoxicity. This mAb has been showed to inhibit the binding of immune complex to NK cells, inhibit cytotoxicity of NK cells, and induce calcium fluxes in NK cells and neutrophils.

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process