TICAM1 anticorps (C-Term)

N° du produit ABIN3029185

Cet anticorps Lapin Polyclonal détecte spécifiquement TICAM1 dans WB, IHC (p) et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour TICAM1 anticorps (C-Term) (ABIN3029185)

Antigène: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TICAM1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-TICAM1 anticorps

Épitope: C-Term

Purification: Antigen affinity

Immunogène: An amino acid sequence from the C-terminus of human TRIF (NNHMWNQRGSQAPEDKTQEAE) was used as the immunogen for this TRIF antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the TRIF antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the TRIF antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur TICAM1

Antigène: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Autre désignation: TRIF

Sujet: TIR Domain-containing adaptor molecule 1, also known as TICAM1 or TRIF, is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al.(2003) mapped the gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al.(2003) showed that the protein interacts specifically with < a href=../search_result.php?search_txt=TLR3>TLR3, but not with other TLRs. Functional analysis showed that the association of TLR3 and TRIF mediates dsRNA activation of IFNB, through either < a href=../search_result.php?search_txt=nfkb>NFKB, < a href=../search_result.php?search_txt=ap1>AP1, or < a href=../search_result.php?search_txt=irf3>IRF3. TRIF activation of NFKB was found to occur predominantly through < a href=../search_result.php?search_txt=irak1>IRAK1 rather than < a href=../search_result.php?search_txt=irak2>IRAK2. siRNA blockage of the protein reduced IFNB production in response to dsRNA.

UniProt: Q8IUC6

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades