Beclin 1 anticorps (AA 1-354)

N° du produit ABIN3030155

L’anticorps anti-Beclin 1 Polyclonal Lapin est utilisé pour la détection de Beclin 1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IF, IP, FACS et IHC (p).

Aperçu rapide pour Beclin 1 anticorps (AA 1-354) (ABIN3030155)

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Beclin 1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Beclin 1 anticorps

Épitope: AA 1-354

Fonction: Beclin 1 Antibody

Purification: Antigen affinity

Immunogène: Human partial recombinant protein (AA 1-354) was used as the immunogen for this Beclin 1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Titration of the Beclin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Beclin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Beclin 1

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Autre désignation: Beclin 1

Sujet: Beclin 1, also known as also known as ATG6 or VPS30 is a protein that in humans is encoded by the BECN1 gene. Beclin 1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. This gene participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Schizophrenia is associated with low levels of the protein in the hippocampus of the affected which causes diminished autophagy which in turn results in increased neuronal cell death. It has been found that Beclin 1 can promote autophagy in autophagy-defective yeast with a targeted disruption of apg6/vps30, and in human MCF7 breast carcinoma cells.

Pathways: Autophagy