Gelsolin anticorps (AA 763-775)

N° du produit ABIN3031036

Détail du produit anti-Gelsolin anticorps

Antigène: Gelsolin (GSN)

Épitope: AA 763-775

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Gelsolin est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: Amino acids 763-775 (WDDDYWSVDPLDR-human) were used as the immunogen for this Gelsolin antibody (100% rat homology).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Gelsolin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Gelsolin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Gelsolin

Antigène: Gelsolin (GSN)

Autre désignation: Gelsolin (GSN Produits)

Synonymes: anticorps ADF, anticorps AGEL, anticorps CG1106, anticorps DGS, anticorps Dmel\\CG1106, anticorps gel, anticorps scin, anticorps cb107, anticorps gsn, anticorps sb:cb107, anticorps u-gelsolin, anticorps wu:fi16f06, anticorps gelsolin, anticorps Gelsolin, anticorps gelsolin S homeolog, anticorps gelsolin a, anticorps GSN, anticorps Gel, anticorps Gsn, anticorps gsn.S, anticorps gsn, anticorps gsna

Sujet: Gelsolin also known as GNS is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. It is one of the most potent members of the actin-severing gelsolin/villin superfamily. The gene was assigned to human chromosome 9q33.2. Gelsolin is also known as brevin, or actin-depolymerizing factor, it is the principal intracellular and extracellular actin-severing protein. Gelsolin and Gc protein together constitute the extracellular actin-scavenger system which prevents the toxic effects of actin release into the extracellular space under circumstances of cell necrosis. It may have therapeutic potential as a mucolytic agent in CF patients. The antiapoptotic activity of Gelsolin seems to prevent a step leading to cytochrome c release from the mitochondria into the cytosol.

UniProt: P06396

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy