GRIA2 anticorps (AA 25-360)

N° du produit ABIN3031067

L’anticorps Lapin Polyclonal anti-GRIA2 a été validé pour WB et IHC (p). Il convient pour détecter GRIA2 dans des échantillons de Humain, Rat et Souris. Il y a 1 publication disponible.

Aperçu rapide pour GRIA2 anticorps (AA 25-360) (ABIN3031067)

Antigène: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIA2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-GRIA2 anticorps

Épitope: AA 25-360

Purification: Antigen affinity

Immunogène: Human partial recombinant protein (AA 25-360) was used as the immunogen for this GLUR2 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the GLUR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the GLUR2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Références pour anticorps anti-GRIA2 (ABIN3031067)

Liu, Woo, Bukhari, Wang, Yan, Buosi, Ermekbaeva, Sista, Kotsiviras, LePochat, Chacko, Zhao, Kang: "Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10." dans: Acta neuropathologica communications, Vol. 10, Issue 1, pp. 95, (2022) (PubMed).

Détails sur GRIA2

Antigène: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Autre désignation: GLUR2

Sujet: Glutamate receptor 2, also known as GLUR2, is a protein that in humans is encoded by the GRIA2 gene. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. The crystal structures of the GLUR2 ligand-binding core in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPA and glutamate. GLUR2 plays a major role in depression at synapses in which glutamate remains in the synaptic cleft for prolonged periods of time during normal operation of the synapse. Overexpression increases dendritic spine size and density in hippocampal neurons, and more remarkably, induces spine formation in GABA-releasing interneurons that normally lack spines.

ID gène: 14800

Pathways: Signalisation PI3K-Akt