MTDH anticorps (AA 101-270)

N° du produit ABIN3031760

L’anticorps Lapin Polyclonal anti-MTDH a été validé pour WB, IHC (p) et ICC. Il convient pour détecter MTDH dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MTDH anticorps (AA 101-270) (ABIN3031760)

Antigène: MTDH (Metadherin (MTDH))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTDH est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Détail du produit anti-MTDH anticorps

Épitope: AA 101-270

Purification: Antigen affinity

Immunogène: Human partial recombinant protein (AA 101-270) was used as the immunogen for this LYRIC antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the LYRIC antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,ICC: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the LYRIC antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur MTDH

Antigène: MTDH (Metadherin (MTDH))

Autre désignation: LYRIC (Metadherin)

Sujet: MTDH (Metadherin), also known as LYRIC or astrocyte elevated gene-1 protein (AEG-1), is a protein that in humans is encoded by the MTDH gene. It is involved in < a href=../search_result.php?search_txt=hif-1 alpha>HIF-1 alpha mediated angiogenesis, interacts with SND1 and is involved in RNA-induced silencing complex (RISC), and plays a very important role in RISC and miRNA functions. LYRIC induces an oncogene called Late SV40 factor (LSF/TFCP2) which is involved in thymidylate synthase (TS) induction and DNA biosynthesis synthesis. Late SV40 factor enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (< a href=../search_result.php?search_txt=mmp9>MMP9). LYRIC acts as an oncogene in melanoma, malignant glioma, breast cancer and hepatocellular carcinoma. It is highly expressed in these cancers and helps in progression and development of these cancers. It is induced by c-Myc oncogene and plays very important role in anchorage independent growth of cancer cells.

ID gène: 92140

Pathways: Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization