CASP5 anticorps (Center)

N° du produit ABIN303202

Cet anticorps Lapin Polyclonal détecte spécifiquement CASP5 dans WB, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CASP5 anticorps (Center) (ABIN303202)

Antigène: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CASP5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CASP5 anticorps

Épitope: Center

Purification: Immunoaffinity Chromatography.

Immunogène: Synthetic peptide corresponding to 14 amino acid peptide from the center of human Caspase-5.

Information d'application

Indications d'application: Immunohistochemistry on Paraffin Sections (5 μg/mL). Immunocytochemistry. Western Blot (0.5-1 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline PBS, containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C to -70 °C for longer. Dilute only prior to immediate use.

Détails sur CASP5

Antigène: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Autre désignation: Caspase-5

Sujet: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1b and IL-18. Caspase-5 can interact with caspase-1, both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1b. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-g.Synonyms: CASP-5, CASP5, ICE(rel)-III, ICH-3 protease, ICH3, TY protease

ID gène: 838

NCBI Accession: NP_001129581

UniProt: P51878

Pathways: Inflammasome