PTTG1 anticorps (AA 146-161)

N° du produit ABIN3032234

L’anticorps anti-PTTG1 Polyclonal Lapin est utilisé pour la détection de PTTG1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour PTTG1 anticorps (AA 146-161) (ABIN3032234)

Antigène: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTTG1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PTTG1 anticorps

Épitope: AA 146-161

Fonction: Securin Antibody

Purification: Antigen affinity

Immunogène: Amino acids 146-161 (LMILDEERELEKLFQL-human) were used as the immunogen for this Securin antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Securin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Securin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PTTG1

Antigène: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Autre désignation: Securin

Sujet: Securin, also known as pituitary tumor-transforming 1 or EAP1 is a protein that in humans is encoded by the PTTG1 gene. The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex(APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. Securin contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box(D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. It is mainly a cytosolic protein, although it partially localizes in the nucleus.

UniProt: O95997