NOTCH2 anticorps (cleaved, Intracellular, N-Term)

N° du produit ABIN303375

Cet anticorps anti-NOTCH2 Polyclonal Lapin (ABIN303375) détecte spécifiquement NOTCH2 dans IHC (p) et EIA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour NOTCH2 anticorps (cleaved, Intracellular, N-Term) (ABIN303375)

Antigène: NOTCH2 (Notch 2 (NOTCH2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOTCH2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-NOTCH2 anticorps

Épitope: cleaved, Intracellular, N-Term

Specificité: This antibody recognises Notch Homolog 2 (NOTCH2).

Purification: Sterile filtration.

Immunogène: Synthetic Peptide corresponding to Amino acid residues of human Notch 2 located near the N-terminal sequence of the Cleaved N Intracellular Domain (NICD).

Information d'application

Indications d'application: Immunohistochemistry on Paraffin Sections (1/500). ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid cycles of freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store vial at-20 °C prior to opening. Aliquot contents and freeze at-20 °C or below for extended storage. Centrifuge product if not completely clear after standing at room temperature.

Détails sur NOTCH2

Antigène: NOTCH2 (Notch 2 (NOTCH2))

Autre désignation: NOTCH2

Sujet: Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.Synonyms: Neurogenic locus notch homolog protein 2, Notch 2, hN2

ID gène: 4853

NCBI Accession: NP_001186930

UniProt: Q04721

Pathways: Signalisation Notch, Stem Cell Maintenance