Estrogen Receptor alpha anticorps (AA 425-595)

N° du produit ABIN3042378

Détail du produit anti-Estrogen Receptor alpha anticorps

Antigène: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Épitope: AA 425-595

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Estrogen Receptor alpha est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Estrogen receptor(ESR1) detection. Tested with WB, IHC-P in Human.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Estrogen receptor(ESR1) detection. Tested with WB, IHC-P in Human.
Gene Name: estrogen receptor 1
Protein Name: Estrogen receptor

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Estrogen Receptor recombinant protein (Position: F425-V595). Human Estrogen Receptor shares 89% and 88% amino acid (aa) sequences identity with mouse and rat Estrogen Receptor, respectively.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for Estrogen Receptor is approximately 0.2 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-Estrogen Receptor alpha (ABIN3042378)

An, Liu, She, Wu, Tian, Shi, Hao, Ren, Yang, Lu, Yang, Wu: "Replication of hepatitis E virus in the ovary and promotion of oocyte apoptosis in rabbits infected with HEV-4." dans: Oncotarget, Vol. 9, Issue 4, pp. 4475-4484, (2018) (PubMed).

Liu, Wang, Zhang, Li, Liu, Miao, Yu: "Diagnostic and prognostic values of contrast‑enhanced ultrasound combined with diffusion‑weighted magnetic resonance imaging in different subtypes of breast cancer." dans: International journal of molecular medicine, Vol. 42, Issue 1, pp. 105-114, (2018) (PubMed).

Ho, Lee, Hsu, Wang, Hsin, Huang, Lee, Lin, Lee: "The ability of 17 β-estradiol to attenuate intrahepatic vasoconstriction to endothelin-1 in female rats is lost in cirrhosis." dans: Annals of hepatology, Vol. 14, Issue 3, pp. 404-13, (2016) (PubMed).

Fu, Zhao, Wu, Wu, Xu, Liu, Tong: "Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure." dans: Journal of ethnopharmacology, Vol. 139, Issue 1, pp. 26-33, (2011) (PubMed).

Deng, Chen, Zhou, Hou: "Letrozole inhibits the osteogenesis of medullary bone in prelay pullets." dans: Poultry science, Vol. 89, Issue 5, pp. 917-23, (2010) (PubMed).

Détails sur Estrogen Receptor alpha

Antigène: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Autre désignation: ESR1 (ESR1 Produits)

Synonymes: anticorps LOC398734, anticorps AA420328, anticorps AU041214, anticorps ER-alpha, anticorps ER[a], anticorps ERa, anticorps ERalpha, anticorps ESR, anticorps Estr, anticorps Estra, anticorps Nr3a1, anticorps NR3A1, anticorps eralpha, anticorps zfER[a], anticorps ER, anticorps ESRA, anticorps ESTRR, anticorps Era, anticorps akap12, anticorps cb27, anticorps esr1, anticorps fb72g12, anticorps id:ibd1202, anticorps sb:cb27, anticorps si:ch73-192g21.1, anticorps wu:fb72g12, anticorps wu:fc21c03, anticorps Esr, anticorps RNESTROR, anticorps ERALPHA, anticorps er, anticorps esr, anticorps nr3a1, anticorps XER, anticorps era, anticorps esra, anticorps ERbeta, anticorps xesr-1, anticorps xlERalpha1, anticorps xlERalpha2, anticorps ESR1, anticorps estrogen receptor 1 L homeolog, anticorps estrogen receptor 1 (alpha), anticorps estrogen receptor 1, anticorps A kinase (PRKA) anchor protein 12b, anticorps esr1.L, anticorps Esr1, anticorps ESR1, anticorps esr1, anticorps akap12b

Sujet: Estrogen receptor alpha (ER-α), also known as NR3A1, is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. In humans, ER-α is encoded by the gene ESR1 (Estrogen Receptor 1). It is mapped to 6q25.1. This gene is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, it also play a role in other tissues such as bone.

Synonyms: Atherosclerosis, susceptibility to, included antibody|DKFZp686N23123 antibody|ER Alpha antibody|ER antibody|ER Beta antibody|ER-alpha antibody|ER[a] antibody|ER[b] antibody|ERA antibody|ERalpha antibody|Erb antibody|Erb2 antibody|ERbeta antibody|ESR 1 antibody|ESR antibody|ESR BETA antibody|ESR1 antibody|ESR1_HUMAN antibody|ESR2 antibody|ESRA antibody|ESRB antibody|Estr antibody|Estra antibody|Estradiol Receptor alpha antibody|Estradiol Receptor antibody|Estradiol Receptor beta antibody|ESTRB antibody|Estrogen receptor 1 (alpha) antibody|Estrogen receptor 1 antibody|Estrogen receptor 2 (ER beta) antibody|Estrogen Receptor 2 antibody|Estrogen receptor 2 ER beta antibody|Estrogen receptor alpha antibody|Estrogen receptor antibody|Estrogen receptor beta 4 antibody|Estrogen resistance, included antibody|HDL cholesterol, augmented response of, to hormone replacement, included antibody|Myocardial infarction, susceptibility to, included antibody|NR3A 1 antibody|NR3A1 antibody|NR3A2 antibody|Nuclear receptor subfamily 3 group A member 1 antibody|Nuclear receptor subfamily 3 group A member 2 antibody|OTTHUMP00000017718 antibody|OTTHUMP00000017719 antibody|RNESTROR antibody

ID gène: 2099

UniProt: P03372

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly