LOX anticorps (Middle Region)

N° du produit ABIN3042506

L’anticorps Lapin Polyclonal anti-LOX a été validé pour WB et ELISA. Il convient pour détecter LOX dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour LOX anticorps (Middle Region) (ABIN3042506)

Antigène: LOX (Lysyl Oxidase (LOX))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LOX est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-LOX anticorps

Épitope: AA 240-268, Middle Region

Fonction: Anti-LOX Antibody Picoband®

Séquence: AEENCLASTA YRADVRDYDH RVLLRFPQR

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-LOX Antibody Picoband® (ABIN3042506). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human LOX, different from the related mouse and rat sequences by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Hamalainen, E.-R., Jones, T. A., Sheer, D., Taskinen, K., Pihlajaniemi, T., Kivirikko, K. I. Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2. Genomics 11: 508-516, 1991. 2. Kuivaniemi, H., Savolainen, E.-R., Kivirikko, K. I. Human placental lysyl oxidase: purification, partial characterization, and preparation of two specific antisera to the enzyme. J. Biol. Chem. 259: 6996-7002, 1984.  3. Li, W., Nellaiappan, K., Strassmaier, T., Graham, L., Thomas, K. M., Kagan, H. M. Localization and activity of lysyl oxidase within nuclei of fibrogenic cells. Proc. Nat. Acad. Sci. 94: 12817-12822, 1997.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur LOX

Antigène: LOX (Lysyl Oxidase (LOX))

Autre désignation: LOX

Sujet:

Synonyms: Protein-lysine 6-oxidase;1.4.3.13;Lysyl oxidase;LOX;

Tissue Specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas. .

Background: Lysyl oxidase  (LOX), also known as protein-lysine 6-oxidase, is a protein that, in humans, is encoded by the LOX gene. The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. 

Poids moléculaire: 31 kDa

ID gène: 4015

UniProt: P28300

Pathways: SARS-CoV-2 Protein Interactome