Oncostatin M anticorps (Middle Region)

N° du produit ABIN3043117

Cet anticorps Lapin Polyclonal détecte spécifiquement Oncostatin M dans WB et IHC. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour Oncostatin M anticorps (Middle Region) (ABIN3043117)

Antigène: Oncostatin M (OSM)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Oncostatin M est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Oncostatin M anticorps

Épitope: AA 181-198, Middle Region

Fonction: Anti-Oncostatin M/OSM Antibody Picoband®

Séquence: ASDAFQRKLE GCRFLHGY

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Oncostatin M/OSM Antibody (ABIN3043117). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human Oncostatin M.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Miles, S. A., Martinez-Maza, O., Rezai, A., Magpantay, L., Kishimoto, T., Nakamura, S., Radka, S. F., Linsley, P. S. Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. Science 255: 1432-1434, 1992. 2. Modur, V., Feldhaus, M. J., Weyrich, A. S., Jicha, D. L., Prescott, S. M., Zimmerman, G. A., McIntyre, T. M. Oncostatin M is a proinflammatory mediator: in vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules. J. Clin. Invest. 100: 158-168, 1997. 3. Rose, T. M., Bruce, A. G. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Nat. Acad. Sci. 88: 8641-8645, 1991.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Oncostatin M (ABIN3043117)

Zhu, Che, Liao, Wang, Wang, Chen, Wang, Dai, Wan: "Oncostatin M activates STAT3 to promote endometrial cancer invasion and angiogenesis." dans: Oncology reports, Vol. 34, Issue 1, pp. 129-38, (2015) (PubMed).

Détails sur Oncostatin M

Antigène: Oncostatin M (OSM)

Autre désignation: OSM

Sujet:

Synonyms: Oncostatin-M,OSM,OSM,

Tissue Specificity: Detected in neutrophils (at protein level). .

Background: OSM (ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The ion of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.

Sequence Similarities: Contains 1 FAD-binding FR-type domain.

Poids moléculaire: 28 kDa

UniProt: P13725

Pathways: Signalistation JAK/STAT, Negative Regulation of Hormone Secretion