Synaptophysin anticorps (N-Term)

N° du produit ABIN3043307

Détail du produit anti-Synaptophysin anticorps

Antigène: Synaptophysin (SYP)

Épitope: AA 1-26, N-Term

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Synaptophysin est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Synaptophysin(SYP) detection. Tested with WB in Human,Mouse,Rat.

Séquence: MLLLADMDVV NQLVAGGQFR VVKEPL

Réactivité croisée (Details): Predicted Cross Reactivity: human
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Synaptophysin(SYP) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: synaptophysin
Protein Name: Synaptophysin

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human Synaptophysin(1-26aa MLLLADMDVVNQLVAGGQFRVVKEPL), identical to the related mouse and rat sequences.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human , The detection limit for Synaptophysin is approximately 0.1 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-Synaptophysin (ABIN3043307)

Chen, Wei, Nie, Lin, Tian, Liu, Yu, Cheng, Yan, Wang, Liu, Deng, Lai, Zhou, Zhang, Lin, Chen: "?-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice." dans: Brain research, Vol. 1552, pp. 41-54, (2014) (PubMed).

Liu, Liang, Liu, Zou, Li, Wang, An: "Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats." dans: Neural regeneration research, Vol. 8, Issue 29, pp. 2725-33, (2014) (PubMed).

Li, Xin, Wang, Wu, Jin, Ma, Nie, Xiao, Hu, Jin: "Pentamethylquercetin protects against diabetes-related cognitive deficits in diabetic Goto-Kakizaki rats." dans: Journal of Alzheimer's disease : JAD, Vol. 34, Issue 3, pp. 755-67, (2013) (PubMed).

Détails sur Synaptophysin

Antigène: Synaptophysin (SYP)

Autre désignation: SYP (SYP Produits)

Synonymes: anticorps syp-B, anticorps xsypii, anticorps MGC86267, anticorps MRXSYP, anticorps A230093K24Rik, anticorps AI848995, anticorps Syn, anticorps p38, anticorps Syp1, anticorps mrxsyp, anticorps syp, anticorps xsypi, anticorps synaptophysin S homeolog, anticorps synaptophysin, anticorps synaptophysin L homeolog, anticorps synaptophysin a, anticorps syp.S, anticorps SYP, anticorps syp, anticorps Syp, anticorps syp.L, anticorps sypa

Sujet: SYP(Synaptophysin) is located on the short arm of X chromosome (Xp11.23-p11.22). The protein is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38 kDa. It is present inneuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors, and its ubiquity at the synapse has led to the use of synaptophysin immunostaining for quantification of synapses. Also, the protein binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR).

Synonyms: Major synaptic vesicle protein P38 antibody|MRXSYP antibody|Syn p38 antibody|Synaptophysin antibody|SYP antibody|SYPH antibody|SYPH_HUMAN antibody|SypI antibody

ID gène: 6855

UniProt: P08247

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity