Tumor Protein p73 anticorps (AA 1-198)

N° du produit ABIN3043469

Détail du produit anti-Tumor Protein p73 anticorps

Antigène: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Épitope: AA 1-198

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tumor Protein p73 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Tumor protein p73(TP73) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Tumor protein p73(TP73) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: tumor protein p73
Protein Name: Tumor protein p73

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human p73 recombinant protein (Position: M1-E198). Human p73 shares 96% amino acid (aa) sequence identity with mouse p73.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for p73 is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-Tumor Protein p73 (ABIN3043469)

Guo, Nan, Hu, Meng, Hui, Zhang, Qin, Sui: "Prognostic significance of co-expression of nm23 and p57 protein in hepatocellular carcinoma." dans: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 40, Issue 11, pp. 1107-16, (2010) (PubMed).

Qin, Nan, Yang, Jing, Ruan, Li, Xu, Guo, Sui, Wei: "Expression and clinical significance of TAp73alpha, p53, PCNA and apoptosis in hepatocellular carcinoma." dans: World journal of gastroenterology, Vol. 11, Issue 18, pp. 2709-13, (2005) (PubMed).

Détails sur Tumor Protein p73

Antigène: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Autre désignation: TP73 (TP73 Produits)

Synonymes: anticorps P73, anticorps Trp73, anticorps TP73, anticorps tp73, anticorps Tp73, anticorps p73, anticorps TAp73, anticorps zp73theta, anticorps tumor protein p73, anticorps transformation related protein 73, anticorps TP73, anticorps Tp73, anticorps tp73, anticorps Trp73

Sujet: P73, also known as tumor protein 73(TP73), encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It is mapped to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Furthermore, recent finding are suggesting that over-expression of transcription factors involved in cell cycle regulation and synthesis of DNA in mammalian cells (e.g.: E2F-1) induces the expression of p73. In addition, p73 is a substrate of the c-Abl kinase and that the ability of c-Abl to phosphorylate p73 is markedly increased by gamma-irradiation.

Synonyms: p53 like transcription factor antibody|p53 Related Protein antibody|p53 Related Protein antibody|p53-like transcription factor antibody|p53-related protein antibody|p73 antibody|P73_HUMAN antibody|TP 73 antibody|TP73 antibody|TP73 antibody|Tumor Protein p73 antibody|Tumor Protein p73 antibody

ID gène: 7161

UniProt: O15350

Pathways: Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus