Lamin B1 anticorps (C-Term)

N° du produit ABIN3043687

Détail du produit anti-Lamin B1 anticorps

Antigène: Lamin B1 (LMNB1)

Épitope: AA 570-586, C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin B1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Fonction: Rabbit IgG polyclonal antibody for Lamin-B1(LMNB1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human,Mouse,Rat.

Séquence: FHQQGTPRAS NRSCAIM

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Lamin-B1(LMNB1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human,Mouse,Rat.
Gene Name: lamin B1
Protein Name: Lamin-B1

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Lamin B1(570-586aa FHQQGTPRASNRSCAIM), different from the related rat sequence by one amino acid, and from the related mouse sequence by three amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staning of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Rat, Predicted Species: Human
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P), IHC(F) and ICC.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-Lamin B1 (ABIN3043687)

Chen, Luo, Lin, Kuang, Song: "Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation." dans: Scientific reports, Vol. 6, pp. 30322, (2018) (PubMed).

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Zhou, Li, Shi, Mao, Liu, Chang, Gan, Kuang, Du: "Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling." dans: Frontiers in pharmacology, Vol. 8, pp. 950, (2018) (PubMed).

Timoshevskiy, Herdy, Keinath, Smith: "Cellular and Molecular Features of Developmentally Programmed Genome Rearrangement in a Vertebrate (Sea Lamprey: Petromyzon marinus)." dans: PLoS genetics, Vol. 12, Issue 6, pp. e1006103, (2017) (PubMed).

Shen, Sun, Xia, Meng, Lei, Zhao, Tang, Xue, Chen: "Overexpression of DJ-1 reduces oxidative stress and attenuates hypoxia/reoxygenation injury in NRK-52E cells exposed to high glucose." dans: International journal of molecular medicine, Vol. 38, Issue 3, pp. 729-36, (2017) (PubMed).

Chen, Jiang, Gu, Lai, Liu, Zhang: "Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway." dans: Environmental toxicology, Vol. 32, Issue 8, pp. 2004-2020, (2017) (PubMed).

Bai, Du, Li, Huang, Deng, Zhou, Chen: "Histone deacetylase-high mobility group box-1 pathway targeted by hypaconitine suppresses the apoptosis of endothelial cells." dans: Experimental biology and medicine (Maywood, N.J.), Vol. 242, Issue 5, pp. 527-535, (2017) (PubMed).

Zhang, Zhang, Zhang, Jiao, Zhang, Wang, Gong: "Glutamine ameliorates lipopolysaccharide-induced cardiac dysfunction by regulating the toll-like receptor 4/mitogen-activated protein kinase/nuclear factor-kB signaling pathway." dans: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5825-5832, (2017) (PubMed).

Tang, Wang, Chen, Xu, Ye: "Clinicopathologic and prognostic significance of p21 (Cip1/Waf1) expression in bladder cancer." dans: International journal of clinical and experimental pathology, Vol. 8, Issue 5, pp. 4999-5007, (2016) (PubMed).

Chen, Lai, Yang, Ruan, Chaugai, Ning, Chen, Wang: "Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1." dans: British journal of pharmacology, Vol. 173, Issue 3, pp. 545-61, (2016) (PubMed).

Bai, Zhang, Shen, Sun, Xia, Zhang, Liu, Wang, Yuan: "Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart." dans: Scientific reports, Vol. 6, pp. 22068, (2016) (PubMed).

Wu, Liu, Duan, Gao, Li, Wang, Song, Shao, Yang, Yang: "The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration." dans: Scientific reports, Vol. 6, pp. 30563, (2016) (PubMed).

Shen, Wang, Wang, Wang, Yang, Shen, Wang, Guo, Liu, Xia, Jia, Wang: "Activation of volume-sensitive outwardly rectifying chloride channel by ROS contributes to ER stress and cardiac contractile dysfunction: involvement of CHOP through Wnt." dans: Cell death & disease, Vol. 5, pp. e1528, (2015) (PubMed).

Zhu, Liu, Li, Liu, Wang, Sun, Xiong, Jiang, Zheng, Hu: "Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility." dans: Carcinogenesis, Vol. 35, Issue 8, pp. 1901-10, (2014) (PubMed).

Liu, Ma, Wu, Li, Zhang, Han, Wang, Reindl, Wu, Ma: "Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-?B signaling." dans: BMC cancer, Vol. 14, pp. 686, (2014) (PubMed).

Gao, Wu, Liu, Li, Song, Teng, Sheng, Liu, Yao, Chen, Jiang, Chen, Huang: "Interaction of NS2 with AIMP2 facilitates the switch from ubiquitination to SUMOylation of M1 in influenza A virus-infected cells." dans: Journal of virology, Vol. 89, Issue 1, pp. 300-11, (2014) (PubMed).

Yu, Chen, Wang, Kuang, Liu, Zhang, Du: "Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-?B and STAT3 in transient focal stroke." dans: PLoS ONE, Vol. 8, Issue 2, pp. e55839, (2013) (PubMed).

Zhang, Zhou, Wu, Zhang, Chen, Zha, Niu, Lu, Hao, Sun, Sun, Peng, Wang: "Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells." dans: British journal of pharmacology, Vol. 165, Issue 1, pp. 120-34, (2012) (PubMed).

Détails sur Lamin B1

Antigène: Lamin B1 (LMNB1)

Autre désignation: LMNB1 (LMNB1 Produits)

Synonymes: anticorps MGC52550, anticorps Lamin-L(I), anticorps lamin-b, anticorps lmn, anticorps lmn2, anticorps lmnb, anticorps LMNB1, anticorps ADLD, anticorps LMN, anticorps LMN2, anticorps LMNB, anticorps fc06g01, anticorps wu:fc06g01, anticorps lamin B1 L homeolog, anticorps lamin B1, anticorps lmnb1.L, anticorps lmnb1, anticorps LMNB1, anticorps Lmnb1

Sujet: Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are though to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.

Synonyms: ADLD antibody|lamin B1 antibody|Lamin-B1 antibody|LMN antibody|LMN2 antibody|LMNB antibody|Lmnb1 antibody|LMNB1_HUMAN antibody|MGC111419 antibody|OTTHUMP00000159218 antibody

UniProt: P20700

Pathways: Apoptose, Caspase Cascade in Apoptosis