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MME anticorps (AA 52-750)

MME Reactivité: Humain, Souris, Rat WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3043879
  • Antigène Voir toutes MME Anticorps
    MME (Membrane Metallo-Endopeptidase (MME))
    Épitope
    • 16
    • 14
    • 10
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 52-750
    Reactivité
    • 213
    • 57
    • 49
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 110
    • 109
    • 2
    Lapin
    Clonalité
    • 116
    • 104
    • 2
    Polyclonal
    Conjugué
    • 108
    • 19
    • 19
    • 14
    • 9
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MME est non-conjugé
    Application
    • 132
    • 101
    • 80
    • 69
    • 38
    • 29
    • 21
    • 21
    • 13
    • 13
    • 10
    • 8
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Fonction
    Rabbit IgG polyclonal antibody for Neprilysin(MME) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Neprilysin(MME) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: membrane metallo-endopeptidase
    Protein Name: Neprilysin
    Purification
    Immunogen affinity purified.
    Immunogène
    E.coli-derived human CD10 recombinant protein (Position: Y52-W750). Human CD10 shares 94% amino acid (aa) sequences identity with both mouse and rat CD10.
    Isotype
    IgG
    Top Product
    Discover our top product MME Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, The detection limit for CD10 is approximately 0.25 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Wang, Tian, Xiao, Zhang, Sun, Tang: "A metanephric adenoma of the kidney associated with polycythemia: A case report." dans: Oncology letters, Vol. 11, Issue 1, pp. 352-354, (2016) (PubMed).

    Meng, Li, Geng, Ohe, Yu, E, Ye, Yang, Kato, Zhang, Ishida, Ohta, Jin, Kakehata, Geng, Yamakawa: "Decreased expression of follicular dendritic cell-secreted protein correlates with increased immunoglobulin A production in the tonsils of individuals with immunoglobulin A nephropathy." dans: Translational research : the journal of laboratory and clinical medicine, Vol. 166, Issue 3, pp. 281-91, (2015) (PubMed).

  • Antigène
    MME (Membrane Metallo-Endopeptidase (MME))
    Autre désignation
    MME (MME Produits)
    Synonymes
    anticorps CALLA, anticorps CD10, anticorps NEP, anticorps SFE, anticorps 6030454K05Rik, anticorps C85356, anticorps Nep, anticorps neprilysin, anticorps membrane metalloendopeptidase, anticorps membrane metallo endopeptidase, anticorps membrane metallo-endopeptidase, anticorps MME, anticorps Mme
    Classe de substances
    Chemical
    Sujet
    CD10, also known as membrane metallo-endopeptidase, neutral endopeptidase(NEP), Neprilysin, or common acute lymphoblastic leukemia antigen(CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably theamyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. This gene is localized to human chromosome 3 by study of somatic cell hybrids and regionalized the location to 3q21-q27 by in situ hybridization. By cDNA transfection analysis, CD10 is confirmed as a functional neutral endopeptidase of the type that has previously been called enkephalinase. CD10 has also been called atriopeptidase. Atriopeptidase specifically degrades atrial natriuretic factor. A specific enzyme inhibitor was developed and reported that it had effects similar to those of low-dose ANF infusion. These effects include diuresis, natriuresis, vasodilatation, and suppression of the renin-angiotensin-aldosterone system.

    Synonyms: Atriopeptidase antibody|CALLA antibody|CD10 antibody|CD10 antigen antibody|Common acute lymphocytic leukemia antigen antibody|DKFZp686O16152 antibody|EC 3.4.24.11 antibody|Enkephalinase antibody|EPN antibody|gp100 antibody|Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase) antibody|Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody|Membrane metallo endopeptidase antibody|Membrane metallo endopeptidase variant 1 antibody|Membrane metallo endopeptidase variant 2 antibody|Membrane metalloendopeptidase antibody|Membrane metalloendopeptidase neutral endopeptidase enkephalinase antibody|Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10 antibody|Membrane metalloendopeptidase variant 1 antibody|Membrane metalloendopeptidase variant 2 antibody|MGC126681 antibody|MGC126707 antibody|MME antibody|NEP antibody|NEP_HUMAN antibody|Neprilysin antibody|Neutral endopeptidase 24.11 antibody|Neutral endopeptidase antibody|SFE antibody|Skin fibroblast elastase antibody
    ID gène
    4311
    UniProt
    P08473
    Pathways
    Signalisation RTK, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration
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