SNRPN anticorps (N-Term)

N° du produit ABIN3043934

Détail du produit anti-SNRPN anticorps

Antigène: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Épitope: AA 11-39, N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNRPN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Small nuclear ribonucleoprotein-associated protein N(SNRPN) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Séquence: QHIDYRMRCI LQDGRIFIGT FKAFDKHMN

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Small nuclear ribonucleoprotein-associated protein N(SNRPN) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: small nuclear ribonucleoprotein polypeptide N
Protein Name: Small nuclear ribonucleoprotein-associated protein N

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human SNRPN (11-39aa QHIDYRMRCILQDGRIFIGTFKAFDKHMN), identical to the related mouse and rat sequences.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for SNRPN is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur SNRPN

Antigène: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Autre désignation: SNRPN (SNRPN Produits)

Synonymes: anticorps SNRB', anticorps SNRPB', anticorps Snrpn, anticorps zgc:77315, anticorps HCERN3, anticorps PWCR, anticorps RT-LI, anticorps SM-D, anticorps SMN, anticorps SNRNP-N, anticorps SNURF-SNRPN, anticorps sm-N, anticorps 2410045I01Rik, anticorps Peg4, anticorps Pwcr1, anticorps FE 294, anticorps FE 294 psi, anticorps FE294, anticorps FE294 psi, anticorps SNURF, anticorps SNRPN, anticorps QflA-11237, anticorps QtrA-10022, anticorps Sm-N, anticorps SmN, anticorps snRNP-N, anticorps small nuclear ribonucleoprotein polypeptide-like, anticorps small nuclear ribonucleoprotein polypeptides B and B1, anticorps small nuclear ribonucleoprotein polypeptide N, anticorps small nuclear ribonucleoprotein N, anticorps small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51, anticorps SNRPN upstream reading frame, anticorps Small nuclear ribonucleoprotein-associated protein N, anticorps SNRPL, anticorps snrpb, anticorps SNRPN, anticorps Snrpn, anticorps snrpn, anticorps SNURF

Sujet: SNRPN(Small Nuclear Ribonucleoprotein Polypeptide N), also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame (SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs (snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the paternal chromosome, suggesting that SNRPN may play a role in its etiology. The SNRPN gene is mapped on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted SNRPN gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.

Synonyms: HCERN3 antibody|PWCR antibody|RSMN_HUMAN antibody|RT LI antibody|RTLI antibody|SM D antibody|Sm N antibody|Sm protein D antibody|Sm protein N antibody|Sm-D antibody|Sm-N antibody|Small nuclear ribonucleoprotein associated protein N antibody|Small nuclear ribonucleoprotein polypeptide N antibody|Small nuclear ribonucleoprotein-associated protein N antibody|SMD antibody|SmN antibody|SNRNP N antibody|snRNP-N antibody|SNRNPN antibody| SNRPN antibody|SNURF SNRPN antibody|Tissue specific splicing protein antibody|Tissue-specific-splicing protein antibody

ID gène: 6638

UniProt: P63162