Tyrosine Hydroxylase anticorps (Middle Region)

N° du produit ABIN3043947

Cet anticorps anti-Tyrosine Hydroxylase est un anticorps Lapin Polyclonal détectant Tyrosine Hydroxylase dans WB, IHC et IF. Adapté pour Rat et Souris. Ce Primary Antibody a été cité dans 10+ publications.

Aperçu rapide pour Tyrosine Hydroxylase anticorps (Middle Region) (ABIN3043947)

Antigène: Tyrosine Hydroxylase (TH)

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tyrosine Hydroxylase est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Tyrosine Hydroxylase anticorps

Épitope: AA 193-222, Middle Region

Fonction: Anti-Tyrosine Hydroxylase/TH Antibody Picoband®

Séquence: KVPWFPRKVS ELDKCHHLVT KFDPDLDLDH

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Rabbit IgG polyclonal antibody for Tyrosine 3-monooxygenase(TH) detection. Tested with WB, IHC-P in Mouse,Rat.
Gene Name: tyrosine hydroxylase
Protein Name: Tyrosine 3-monooxygenase

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human Tyrosine Hydroxylase, identical to the related mouse and rat sequences.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
Immunofluorescence, 5 μg/mL, Mouse, Rat
1. Haavik J, Toska K (June 1998). "Tyrosine hydroxylase and Parkinson's disease". Mol. Neurobiol. 16 (3): 285-309. 2. Kaufman S (1995). "Tyrosine hydroxylase". Adv. Enzymol. Relat. Areas Mol. Biol. Advances in Enzymology - and Related Areas of Molecular Biology 70: 103-220. Nagatsu T (1995). "Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology". Essays Biochem.30: 15-35.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Références pour anticorps anti-Tyrosine Hydroxylase (ABIN3043947)

Hu, Wang, Ren, Liu: "Autonomic remodeling may be responsible for decreased incidence of aortic dissection in STZ-induced diabetic rats via down-regulation of matrix metalloprotease 2." dans: BMC cardiovascular disorders, Vol. 16, Issue 1, pp. 200, (2017) (PubMed).

Su, Fu, Zhang, Shi, Zhang, Gao: "Identification and expression of SRF targeted by miR-133a during early development of Paralichthys olivaceus." dans: Fish physiology and biochemistry, Vol. 41, Issue 5, pp. 1093-104, (2015) (PubMed).

Deng, Jiao, Mi, Xu, Li, Wang, Liu, Xu: "Melatonin inhibits manganese-induced motor dysfunction and neuronal loss in mice: involvement of oxidative stress and dopaminergic neurodegeneration." dans: Molecular neurobiology, Vol. 51, Issue 1, pp. 68-88, (2015) (PubMed).

Li, Jiang, Jiang, Yang, Ma, Yang: "Effect of Guizhi Decoction ([symbols; see text]) on heart rate variability and regulation of cardiac autonomic nervous imbalance in diabetes mellitus rats." dans: Chinese journal of integrative medicine, Vol. 20, Issue 7, pp. 524-33, (2014) (PubMed).

Zhao, Cheng, Fan, Yang, Ye, Cui, Wei, Lao, Cai, Han, Rong et al.: "Botanical drug puerarin coordinates with nerve growth factor in the regulation of neuronal survival and neuritogenesis via activating ERK1/2 and PI3K/Akt signaling pathways in the neurite extension ..." dans: CNS neuroscience & therapeutics, Vol. 21, Issue 1, pp. 61-70, (2014) (PubMed).

Huang, Zhu, Zhang, Zhu, Liu, Zhu, Wang, Li, Yang, Dong, Liu, Chen, Zhang, Yang, Deng, Fan, Wang, Liu, Ma, Fu, Wu: "S100+ cells: a new neuro-immune cross-talkers in lymph organs." dans: Scientific reports, Vol. 3, pp. 1114, (2013) (PubMed).

Hu, Ye, Wang, Zhang, Chen, Guo: "Bone morphogenetic proteins induce rabbit bone marrow-derived mesenchyme stem cells to differentiate into osteoblasts via BMP signals pathway." dans: Artificial cells, nanomedicine, and biotechnology, Vol. 41, Issue 4, pp. 249-54, (2013) (PubMed).

Wan, Liu, Liu, Cai, Chen: "Effect of adenovirus-mediated brain derived neurotrophic factor in early retinal neuropathy of diabetes in rats." dans: International journal of ophthalmology, Vol. 3, Issue 2, pp. 145-8, (2012) (PubMed).

Wu, Ge, Zeng, Zhang: "Induced multilineage differentiation of chicken embryonic germ cells via embryoid body formation." dans: Stem cells and development, Vol. 19, Issue 2, pp. 195-202, (2010) (PubMed).

Wu, Zhao, Zhu, Peng, Jia, Wu, Zheng, Wu: "A novel function of microRNA let-7d in regulation of galectin-3 expression in attention deficit hyperactivity disorder rat brain." dans: Brain pathology (Zurich, Switzerland), Vol. 20, Issue 6, pp. 1042-54, (2010) (PubMed).

Détails sur Tyrosine Hydroxylase

Antigène: Tyrosine Hydroxylase (TH)

Autre désignation: Tyrosine Hydroxylase

Sujet:

Synonyms: Tyrosine 3-monooxygenase,1.14.16.2,Tyrosine 3-hydroxylase,TH,TH,TYH,

Tissue Specificity: Mainly expressed in the brain and adrenal glands.

Background: TH is equal to tyrosine hydroxylase. The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral sympathetic neurons and the adrenal medulla. Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases (AAAHs).

Sequence Similarities: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Poids moléculaire: 59 kDa

ID gène: 7054

UniProt: P07101

Pathways: Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour