Lamin B2 anticorps (C-Term)

N° du produit ABIN3044232

Cet anticorps anti-Lamin B2 est un anticorps Lapin Polyclonal détectant Lamin B2 dans WB, IHC et IHC (fro). Adapté pour Humain, Souris et Rat. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour Lamin B2 anticorps (C-Term) (ABIN3044232)

Antigène: Lamin B2 (LMNB2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin B2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Lamin B2 anticorps

Épitope: AA 580-597, C-Term

Fonction: Anti-Lamin B2/LMNB2 Antibody Picoband®

Séquence: EEDLFHQQGD PRTTSRGC

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Lamin B2/LMNB2 Antibody (ABIN3044232). Tested in IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Lamin B2, identical to the related rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Rat
1. Biamonti, G., Giacca, M., Perini, G., Contreas, G., Zentilin, L., Weighardt, F., Guerra, M., Della Valle, G., Saccone, S., Riva, S., Falaschi, A. The gene for a novel human lamin maps at a highly transcribed locus of chromosome 19 which replicates at the onset of S-phase. Molec. Cell. Biol. 2. Giacca, M., Zentilin, L., Norio, P., Diviacco, S., Dimitrova, D., Contreas, G., Biamonti, G., Perini, G., Weighardt, F., Riva, S., Falaschi, A. Fine mapping of a replication origin of human DNA. Proc. Nat. Acad. Sci. 91: 7119-7123, 1994.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.01 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Lamin B2 (ABIN3044232)

Chen, Jiang, Gu, Lai, Liu, Zhang: "Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway." dans: Environmental toxicology, Vol. 32, Issue 8, pp. 2004-2020, (2017) (PubMed).

Détails sur Lamin B2

Antigène: Lamin B2 (LMNB2)

Autre désignation: LMNB2

Sujet:

Synonyms: Lamin-B2,LMNB2,LMN2,

Tissue Specificity: Lung, testis and peripheral blood mononuclear cells.

Background: Lamin B2, also called LMNB2, is a protein associated with laminopathies. The LMNB2 gene is mapped to the G-negative subtelomeric band p13.3 of chromosome 19 by in situ hybridization. The LMNB2 gene contains 12 exons. < a href="https://www.bosterbio.com/blog/post/how-to-choose-a-model-organism" style="color:#EA8D28">Common model organisms have been used in the study of Lamin B2 function. A conditional knockout mouse line, called Lmnb2, is generated as part of the International Knockout Mouse Consortium program-a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. A highly sensitive procedure about mapping the start site of DNA replication in a 13.7-kb region of human chromosome 19 coding for lamin B2 is developed for the identification of the origin of biional DNA synthesis in single-copy replicons of mammalian cells.

Sequence Similarities: Belongs to the intermediate filament family.

Poids moléculaire: 70 kDa

UniProt: Q03252

Pathways: Apoptose, Caspase Cascade in Apoptosis