TRF1 anticorps
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- Antigène Voir toutes TRF1 (TERF1) Anticorps
- TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TRF1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
- Specificité
- This antibody recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60 kDa protein.
- Attributs du produit
- Synonyms: PIN2, TRBF1, TRF, TRF1, Telomeric repeat-binding factor 1, TTAGGG repeat-binding factor 1,NIMA-interacting protein 2, Telomeric protein Pin2/TRF1
- Purification
- Purified IgG prepared by affinity chromatography on Protein G
- Immunogène
- Recombinant TRF1
- Clone
- BED5
- Isotype
- IgG1
- Top Product
- Discover our top product TERF1 Anticorps primaire
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- Indications d'application
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Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections: 1/200 - 1/1000, This product requires antigenretrieval using heat treatment prior to staining of paraffin sections, Sodium citrate buffer pH 6.0 is recommended for this purpose. ELISA. Western Blot: detects a band of approximately 60 kDa in Jurkat whole cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS pH 7.4 containing 0.09 % Sodium Azide as preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. Caution: (A full Health and Safety assessment is available upon request) This product containsSodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled bytrained staff only. - Date de péremption
- 12 months
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- Antigène
- TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))
- Autre désignation
- TERF1 (TERF1 Produits)
- Synonymes
- anticorps PIN2, anticorps TRBF1, anticorps TRF, anticorps TRF1, anticorps hTRF1-AS, anticorps t-TRF1, anticorps wu:fb74c04, anticorps TERF1, anticorps DKFZp459A0713, anticorps Pin2, anticorps Trbf1, anticorps Trf1, anticorps terf1, anticorps trf1, anticorps telomeric repeat binding factor 1, anticorps telomeric repeat binding factor (NIMA-interacting) 1, anticorps telomeric repeat binding factor (NIMA-interacting) 1 L homeolog, anticorps TERF1, anticorps Terf1, anticorps terf1, anticorps Trf1, anticorps terf1.L
- Sujet
- Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. TRF1 is thought to play a role in leukaemia being expressed at significantly higher levels in patients with acute lymphoblastic leukaemia than those with myeloid leukaemia.Synonyms: NIMA-interacting protein 2, PIN2, TRBF1, TRF, TRF1, TTAGGG repeat-binding factor 1, Telomeric protein Pin2/TRF1, Telomeric repeat-binding factor 1
- ID gène
- 7013
- UniProt
- P54274
- Pathways
- Cycle Cellulaire, Telomere Maintenance, Hormone Transport, Chromatin Binding, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity
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