IRF3 anticorps (AA 108-166)

N° du produit ABIN317099

Cet anticorps anti-IRF3 est un anticorps Souris Monoclonal détectant IRF3 dans WB et EIA. Adapté pour Humain.

Aperçu rapide pour IRF3 anticorps (AA 108-166) (ABIN317099)

Antigène: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IRF3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 3F10

Détail du produit anti-IRF3 anticorps

Épitope: AA 108-166

Specificité: The antibody recognizes human interferon regulatory factor 3 (IRF3), a 55 kDa constitutively expressed member of the IRF family. Other species not tested.

Attributs du produit: Synonyms: Interferon regulatory factor 3, IRF-3

Purification: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogène: Recombinant human IRF3 (108-166 aa) purified from E. coli

Isotype: IgG1

Information d'application

Indications d'application: ELISA. Western blot (1: 1,000 - 1: 3,000), recommended starting dilution is 1: 2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 10 % glycerol and 0.01 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur IRF3

Antigène: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Autre désignation: IRF3

Sujet: Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF3 accumulates in an inactive form in the cytoplasm and then translocates to the nucleus as a homodimer, following stimuli-induced phosphorylation of specific serine/threonine residues. Association of the homodimer with p300/CBP (CREBB binding protein) forms dsRNA-activated factor 1 (DRAF1), which then activates the transcription of interferon alpha and beta, along with other interferon-induced genes.Synonyms: IRF-3, Interferon regulatory factor 3

ID gène: 3661

UniProt: Q14653

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades