IRF3 anticorps (AA 108-166)
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- Antigène Voir toutes IRF3 Anticorps
- IRF3 (Interferon Regulatory Factor 3 (IRF3))
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Épitope
- AA 108-166
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp IRF3 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificité
- The antibody recognizes human interferon regulatory factor 3 (IRF3), a 55 kDa constitutively expressed member of the IRF family. Other species not tested.
- Attributs du produit
- Synonyms: Interferon regulatory factor 3, IRF-3
- Purification
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Immunogène
- Recombinant human IRF3 (108-166 aa) purified from E. coli
- Clone
- 3F10
- Isotype
- IgG1
- Top Product
- Discover our top product IRF3 Anticorps primaire
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- Indications d'application
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ELISA. Western blot (1: 1,000 - 1: 3,000), recommended starting dilution is 1: 2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.0 mg/mL
- Buffer
- PBS, pH 7.4, containing 10 % glycerol and 0.01 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - Date de péremption
- 12 months
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- Antigène
- IRF3 (Interferon Regulatory Factor 3 (IRF3))
- Autre désignation
- IRF3 (IRF3 Produits)
- Synonymes
- anticorps irf3, anticorps IRF3, anticorps C920001K05Rik, anticorps IRF-3, anticorps interferon regulatory factor 3, anticorps interferon regulatory factor 7, anticorps irf3, anticorps IRF3, anticorps irf-3, anticorps Irf3, anticorps IRF7
- Sujet
- Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF3 accumulates in an inactive form in the cytoplasm and then translocates to the nucleus as a homodimer, following stimuli-induced phosphorylation of specific serine/threonine residues. Association of the homodimer with p300/CBP (CREBB binding protein) forms dsRNA-activated factor 1 (DRAF1), which then activates the transcription of interferon alpha and beta, along with other interferon-induced genes.Synonyms: IRF-3, Interferon regulatory factor 3
- ID gène
- 3661
- UniProt
- Q14653
- Pathways
- Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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