IL12B anticorps

N° du produit ABIN317391

Détail du produit anti-IL12B anticorps

Antigène: IL12B (Interleukin 12 beta (IL12B))

Reactivité: Humain, Mouton, Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL12B est non-conjugé

Application: Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Functional Studies (Func)

Specificité: This antibody recognizes Interleukin-12. It has been shown to block the biological activity of IL-12.

Attributs du produit: Synonyms: Interleukin-12B, IL-12B, IL-12 subunit p40, CLMF p40, NKSF2, Cytotoxic lymphocytematuration factor 40 kDa subunit, NK cell stimulatory factor chain 2

Purification: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogène: Recombinant bovine IL-12

Clone: CC326

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: 1/100 - 1/1000. Flow cytometry: 1/1000, use 10 μL to label 10^6 cells of 100 l. Functional assays: 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, None, None

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Date de péremption: 12 months

Détails sur IL12B

Antigène: IL12B (Interleukin 12 beta (IL12B))

Autre désignation: Interleukin-12 beta / IL12B (IL12B Produits)

Synonymes: anticorps CLMF, anticorps CLMF2, anticorps IL-12B, anticorps NKSF, anticorps NKSF2, anticorps p40, anticorps Il-12b, anticorps Il12p40, anticorps Il-12p40, anticorps Il12, anticorps IL-12p40, anticorps IL-12, anticorps IL-12 p40, anticorps il12b, anticorps il12p40.b, anticorps zgc:152789, anticorps IL-12.p40, anticorps IL12p40, anticorps IL12B, anticorps CLMF p40, anticorps interleukin 12B, anticorps interleukin 12b, anticorps interleukin 12Ba, anticorps IL12B, anticorps Il12b, anticorps il12ba

Sujet: Interleukin 12 (IL12) can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine activated killer cells, and stimulate the production of IFN gamma by resting PBMC. IL12 induces IFN gamma, TNF alpha production in T and NK cells, costimulation of PBL proliferation, proliferation/differentiation of TH1 T lymphocytes. It is downregulated by IL10, homodimeric p40 antagonistic to functional p70 heterodimer. IL12R beta 1 binds p40 but when dimeric with IL12R beta 2 binds p35.Synonyms: CLMF p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, IL-12B, Interleukin-12B, NK cell stimulatory factor chain 2, NKSF2

ID gène: 281857

UniProt: P46282

Pathways: Signalistation JAK/STAT, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation