PAWR anticorps

N° du produit ABIN317874

Cet anticorps anti-PAWR Polyclonal Lapin (ABIN317874) détecte spécifiquement PAWR dans WB et IF. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PAWR anticorps (ABIN317874)

Antigène: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAWR est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-PAWR anticorps

Specificité: PAR-4 antibody detects endogenous levels of PAR-4 protein.(region surrounding Arg68)

Purification: Affinity chromatography

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PAWR

Antigène: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Autre désignation: PAR4 / PAWR

Sujet: Normal tissues are characterized by a balance between cellular stasis, cell proliferation, cell differentiation and cell death. Aberrant regulation of any of these cell processes can result in cancer. Cell death during embryogenesis, tissue atrophy and normal tissue turnover is called apoptosis and is characterized by cytoplasmic and nuclear condensation, nuclear disorganization and fragmentation of genomic DNA into 180-200 base pair oligomers. Five ionomycin-inducible complementary cDNAs, designated PAR1, 2, 3, 4 and 5, have been isolated from the prostate cancer cell line AT-3. Nucleotide sequencing identified PAR1 as the rat homolog of MKP-1, PAR2 as the injury-inducible gene HB-EGF, and PAR3 as the serum-induced gene Cyr61. PAR4 and PAR5 sequences were not found to correspond to any previously described proteins. PAR4 (prostate apoptosis response 4) is specifically expressed by cells entering apoptosis and is not induced during growth factor stimulation, oxidative stress, necrosis or growth arrest. The PAR4 gene encodes a protein with a putative nuclear localization signal and carboxy terminal leucine zipper.Synonyms: PRKC apoptosis WT1 regulator protein, Par-4, Prostate apoptosis response 4 protein

Poids moléculaire: approx. 38 kDa

ID gène: 5074

NCBI Accession: NP_002574

UniProt: Q96IZ0