UNG anticorps (N-Term)

N° du produit ABIN318787

Cet anticorps Lapin Polyclonal détecte spécifiquement UNG dans WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour UNG anticorps (N-Term) (ABIN318787)

Antigène: UNG (Uracil-DNA Glycosylase (UNG))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UNG est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-UNG anticorps

Épitope: N-Term

Specificité: This antibody recognises uracil-DNA glycosylase 1 (UNG1), a member of the uracil-DNA glycosylase and cyclin family.

Purification: Purified

Immunogène: 14 amino acid peptide sequence near the amino terminus of human UNG1.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 0.5 - 1.0g/mL, detects a band of approximately 34.6 kDa in C2C/2 celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur UNG

Antigène: UNG (Uracil-DNA Glycosylase (UNG))

Sujet: Two isoforms of UNG exist, isoform 1 is expressed in the mitochondria of in skeletal muscle, heart and testicles while isoform 2 (UNG2) is more abundant in proliferating tissues and expressed in the nucleus. Uracil residues can be misincorporated into DNA by DNA polymerase or by deamination of cytosine. UNG1 is a major enzyme in base excision repair, excising the misincorporated uracil residues in a process crucial to increasing immunoglobulin diversity. In association with activation-induced cytosine deaminase, UNG is also essential to the generation of strand breaks that initiate class switch recombination. UNG is also involved in the innate immune response against retroviral infections, HIV-1 accessory protein Vpr induces the rapid degradation of UNG2.Synonyms: DGU, UDG, UNG1, UNG15

ID gène: 7374

NCBI Accession: NP_003353

UniProt: P13051

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response