DLL4 anticorps (Internal Region)

N° du produit ABIN318838

Détail du produit anti-DLL4 anticorps

Antigène: DLL4 (delta-Like 4 (DLL4))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DLL4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects human Delta-like ligand 4 (DLL4), also known as Delta-4.

Purification: Purified

Immunogène: Synthetic peptide corresponding to the internal region of human DLL4.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry on paraffin sections: 5 - 15g/mL. ELISA: 1: 3000 - 1: 15000. Western Blot: 1: 300 - 1: 1500, detects a band of approximately 74 kDa in pancreatic celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0mg/mL

Buffer: Phosphate buffered saline pH 7.2 containing 0.09 % Sodium Azide (NaN3)

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-DLL4 (ABIN318838)

Wang, Lu, Zhang, Du, Tang, Wang, Lu, Hu: "GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway." dans: Mediators of inflammation, Vol. 2016, pp. 2853040, (2017) (PubMed).

Li, Yan, Wang, Jing, Li, Liu, Yu, Fan: "Effects of canonical NF-κB signaling pathway on the proliferation and odonto/osteogenic differentiation of human stem cells from apical papilla." dans: BioMed research international, Vol. 2014, pp. 319651, (2014) (PubMed).

Villaamil, Gallego, Valladares-Ayerbes, Caínzos, Aparicio: "Multiple biomarker tissue arrays: A computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway." dans: Journal of molecular signaling, Vol. 7, Issue 1, pp. 14, (2012) (PubMed).

González-Mariscal, Garay, Quirós: "Identification of claudins by western blot and immunofluorescence in different cell lines and tissues." dans: Methods in molecular biology (Clifton, N.J.), Vol. 762, pp. 213-31, (2011) (PubMed).

Détails sur DLL4

Antigène: DLL4 (delta-Like 4 (DLL4))

Autre désignation: delta-Like Protein 4 / DLL4 (DLL4 Produits)

Synonymes: anticorps hdelta2, anticorps Delta4, anticorps si:ch211-244p18.5, anticorps zgc:136596, anticorps delta like canonical Notch ligand 4, anticorps delta-like 4 (Drosophila), anticorps DLL4, anticorps Dll4, anticorps dll4

Sujet: DLL4 is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the Notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumour vessels of clear-cell renal tumours and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumour growth, with no apparent toxicity.Synonyms: Delta 4, Drosophila Delta homolog 4

ID gène: 54567

NCBI Accession: NP_061947

UniProt: Q9NR61

Pathways: Signalisation Notch