Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificité
This antibody recognises Carabin, also known as TBC1 domain family member 10C (TBC1D10C), a 50 kDa protein belonging to the TBC1 domain family of proteins. This antibody does not cross react with either TBC1D10A or TBC1D10B.
Purification
Purified
Immunogène
A 17 amino acid peptide from near the amino terminus of human Carabin.
TBC1D10C
Reactivité: Humain, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Porc
WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Western Blot: 1 - 2g/mL, detects a band of approximately 55 kDa in human spleen tissuecell lysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
anticorps CARABIN, anticorps EPI64C, anticorps 1810062O14Rik, anticorps AI428527, anticorps RGD1311490, anticorps TBC1 domain family member 10C, anticorps TBC1 domain family, member 10c, anticorps TBC1 domain family, member 10C, anticorps TBC1D10C, anticorps Tbc1d10c
Sujet
Carabin differs from other members of the TBC1 domain protein family, which appear to play a role in the regulation of cell growth and differentiation. Studies demonstrate that Carabin is part of a negative regulatory loop for the intracellular TCR signalling pathway and acts as an inhibitor of the Ras signalling pathway. Carabin is also believed to mediate crosstalk between calcineurin and Ras. Carabin is most abundantly expressed in spleen and peripheral blood leucocytes.Synonyms: TBC1 domain family member 10C, TBC1D10C